Results
| PMID | 11526787 |
| Gene Name | IFNG |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 19 |
| Population details | 19 (9 infertile women with minimal or mild endometriosis and 10 patients with tubal occlusion (the reference group)) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | TNF-alpha, IFN-gamma |
| Other associated phenotypes |
Endometriosis associated infertility |
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Ginekol Pol. 2001 May;72(5):422-6. Polak, G| Koziol-Montewka, M| Niedzwiadek, J| Tarkowski, R| Sidor-Wojtowicz, A| Kotarski, J Katedry i Zakladu Mikrobiologii Lekarskiej AM w Lublinie. OBJECTIVES: To assess the concentrations of tumor necrosis factor alpha (TNF-alpha), interferon gamma (IFN-gamma) and lipid peroxides (the marker of free radicals activity) in peritoneal fluid (PF) of infertile women with minimal and mild endometriosis. MATERIALS AND METHODS: 19 women were studied, including 9 infertile women with minimal or mild endometriosis and 10 patients with tubal occlusion (the reference group). Lipid peroxides (malonyldialdehyde and 4-hydroxynonenal), TNF-alpha and IFN-gamma concentrations were measured in the PF using commercially available kits. RESULTS: Concentration of IFN-gamma was detectable in PF of 7 (77.8%) women with endometriosis and in PF from 3 (30%) patients with tubal occlusion. Neither TNF-alpha or lipid peroxides PF concentration differed significantly (p < 0.05) between the groups. In the group with endometriosis we have found a positive correlation (R = 0.77, p = 0.04) between the concentrations of TNF-alpha and IFN-gamma. CONCLUSIONS: Our results suggest that oxidative stress in the PF doesn't appear to play a role in endometriosis-associated infertility. Mesh Terms: Adult| Ascitic Fluid/metabolism| Endometriosis/complications/diagnosis/*metabolism| Female| Humans| Infertility, Female/etiology| Interferon-gamma/*metabolism| Lipid Peroxides/*metabolism| Pelvic Inflammatory Disease/complications/diagnosis/*metab |
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